Pentoxifylline (Trendal) is like caffeine or theophylline. Other brand names included is Pentox.
Pentoxifylline is an agent that is used to regenerate blood flow by degenerating blood resistance and by developing red cell pliancy. Pentoxifylline also degenerates leukocyte damage and inhibits neutrophil adhesions and activation. The microcirculation is the main application in this treatment. In such situations, Pentoxifylline is used for tissue blood flow, oxygenation increase in the tissue and tissue flexibility and viability.
Use in Treatment
Pentoxifylline is used to treat such conditions as ear margin vasculitis, blood vessel inflammation and even may be beneficial in treating chronic bronchitis.
Pentoxifylline is beneficial in treating collies and shelties, which genetically contract a condition called familial canine dermatomyositis. This condition attacks the skin and muscular parts of the anatomy.
Numerous skin conditions can cause incessant scratching in pets. The most common condition that will cause this is atopic dermatitis. The feet, ear and muzzle is more affected than other parts of the body and can be more severe in warm or hot climates. Tests must be completed to explore what allergens may be causing your pet’s discomfort. Pentoxifylline is one of the most common anti-inflammatory agents prescribed to keep this condition under control. You may want to go a bit further with treatment and investigate your pet’s diet also. You may want to make some slight changes into what your pet is eating, if allerigies to food is discovered.
Pentoxifylline treats the increase in blood flow. It is also used for blood clots, along with pain medications and intravenous fluids. Blood clots are not only fatal to humans, but it is also fatal to our furry friends. Early diagnosis is a key factor to treating this condition and saving the life of your pet. If your pet shows any signs of difficulty breathing, staggering in their gait, listlessness or no movement, or showing no response to stimuli, take your pet to the veterinarian immediately.
Treatment, with use of this medication, can take weeks to months before appreciative evidence of improvement is seen.
Although, Pentoxifylline has many adverse effects in humans, veterinary experience is very limited and adverse effects maybe different. Medically and scientifically documentation has stated that this medication does affect the GI tract, vomiting and diarrhea has been warranted by oral dosage. Due to its anti-coagulate effect on the bloodstream, retinal or cerebral bleed can occur. If this medication is prescribed, be vigilant and watch for signs that may be a health concern for your pet.
The usual dosage in dogs is 5 to 12.5 mg per pound (10 to 25 mg/kg) every 12 to 24 hours.